SIGNATURE WORK
CONFERENCE & EXHIBITION 2022

Previous studies found that higher resting heart rate (HR) was associated with higher mortality in adults, but there is few research on centenarians. We aimed to investigate the effects of HR on all-cause mortality among Chinese centenarians. A total of 9,863 subjects (1,943 men, 7,920 women) recruited from 1998-2014 in the first seven waves of the Chinese Longitudinal Healthy Longevity Survey were followed up until 2018. HR was classified into four groups: = 90 (n=699) beat per minute. Analyses adjusted for age, marital status, residence, co-residence, diet, physical activity, smoking and drinking. In multivariable-adjusted Cox proportional hazard regression models, the hazard ratio (95% confidence interval) for mortality was 1.04 (0.99 to 1.10), 1.09 (1.02 to 1.17), and 1.16 (1.05 to 1.29) for those in the 70-79, 80-89, and >= 90 groups respectively, compared with the lowest HR group for women. For men, it was 0.94 (0.83 to 1.05), 0.92 (0.84 to 1.13), and 0.98 (0.73 to 1.15). Results were robust after additional adjustment for cognition, disease history, and physical functioning. Among female centenarians, we found higher HR was associated with a higher risk of mortality. This was not confirmed in men, possibly due to small sample size, which requires future research.