SIGNATURE WORK
CONFERENCE & EXHIBITION 2022

Retinoblastoma is a common pediatric retinal cancer that affects children worldwide. Numerous studies on retinoblastoma relevant to RB1 gene loss-of-function have been done, but there are relatively limited amounts of information on retinoblastoma without RB1 gene malfunction. It is identified that non-rb1 retinoblastoma is mainly due to mutations in MYCN gene and is categorized as trilateral retinoblastoma as it causes brain metastasis with poor prognosis among patients. In this study, potential significant SNPs and/or mutations were identified across trilateral retinoblastoma, using non-rb1 retinoblastoma cell line Y79. In addition, it has been identified in this study that mitotic blocker colchicine has a potential role in increasing cell death across trilateral retinoblastoma cells. These results would be helpful in future studies on cellular mechanisms and potential therapeutics for metastatic retinoblastoma and other metastatic cancers.