| Many mathematical and statistical methods have been applied to biological research, especially genetic analysis. During the COVID‐19 pandemic in the past three years, genetic analysis has been significant and indispensable to studying related viruses and their multiple mutant variants, and sequence matching is one of the most essential parts of genetic analysis, which is to figure out the origin of genes. In this paper, I am going to introduce the Chen‐Stein Method, a powerful technique known that can be applied to find a good approximation for distributions of a sum of weakly dependent Bernoulli random variables, and describe how it can be used to solve the DNA and RNA sequence matching problem. Relevant mathematical knowledge and biological terminology will be provided in advance, and both mathematical proof and verification by simulation will be involved when introducing the process of the application. Furthermore, the potential limitations of this application will be discussed. |
