The world is aging. As the oldest-old population is increasing rapidly and those are the population that needs more healthcare services and attention from society, understanding the effect of lifestyles on mortality can help provide valuable instructions for the oldest-old population. Previous studies had investigated the association between an individual modifiable lifestyle with mortality. However, influences of combined lifestyles on mortality risks remain inconclusive among adults aged 80 years or older (“oldest-old”). Using the Chinese Longitudinal Healthy Longevity Survey (CLHLS), we investigated the association of time-varying healthy lifestyle profile (HLP) with mortality among Chinese oldest-old adults.