SIGNATURE WORK
CONFERENCE & EXHIBITION 2023

The mutant allele (*2) of aldehyde dehydrogenase type 2 (ALDH2) caused by a single nucleotide variant (rs671) inhibits enzymatic activity and is associated with multiple diseases. This quantitative umbrella review aimed to investigate the associations between ALDH 2 genotypes and complex diseases, mainly including cardio-cerebral vascular disease, diabetes mellitus, cancer, neurodegenerative disease, and alcohol-induced medical disease. The search was conducted in PubMed, Medline Ovid, Embase, Cochrane Database of Systematic Reviews, and Web of Science. Eligible systematic reviews published before July 1st, 2022 were included. The review was conducted using standardized and customized methods to address overlapping data and conflicting results. The findings of this umbrella review provided a systematic understanding of the association between ALDH2 rs671 and diseases and provided applicable methods for future umbrella reviews of meta-analyses on genetic association studies. The prevalence of bias, overlapping and errors detected in included systematic reviews calls for further studies to confirm our findings and explore the underlying mechanisms of genotype-outcome associations.