The COVID-19 pandemic and the development of social media have provided a fertile ground for disseminating fake news, posing a significant threat to public health. In response, scientists in multiple disciplines have tried to study the pattern and impact of fake news before and during the pandemic. Currently, systematic reviews for the pattern and impact of fake news exist, most only dwelling on single disciplines; a literature gap exists in reviewing interventions proposed in tackling COVID-related infodemic in an interdisciplinary view. Therefore, the present study aims to provide a systematic review of interventions in countering fake news congregating multiple disciplines. By adopting PRISMA, 11 articles were reviewed as eligible among three academic databases and synthesized for the proposed interventions in comparison of different disciplines and methodologies. The present study concludes the segmentation between different interventions and academic perspectives, shedding light on the direction of future studies and how different parties can act together in combating the wicked problem of fake news in times of crisis.