OSW

SIGNATURE WORK
CONFERENCE & EXHIBITION 2023

Exploring gluco-conjugated imidazoyl[1,10]phenanthroline ligands bearing fluoro units connected to a Ruthenium (Ru) core and the complexes’ biology potential

Name

Zijun Xie

Major

Environmental science/ Chemistry

Class

2023

About

I am Zijun Xie from Class of 2023 and I have been majored in Environmental Science-Chemistry Track in my Undergraduate study.

Signature Work Project Overview

“The primary goal of the study is to examine the biological potential of complexes having phenanthroline/fə’nænθrəli:n/ ligands with fluoro units connected to a Ruthenium (Ru) core. Although platinum medications have been demonstrated to have severe side effects, such as omiting, losing hair, and neurotoxicity, ruthenium compounds have been extensively explored as potential replacements to platinum for clinical development. Ruthenium (II)-centered compounds have garnered the most interest among these metal centers due to their low toxicity, moderate side effects, strong selectivity for healthy cells and tissues, and potent anticancer activity. We want to synthesize a novel metal complex whose structure is comparable to TLD-1433 and its derivatives, but with a different functional group involving the presence of a fluorine atom. The potential biological target of metal complexes is evaluated by how they interact with DNA. “

Signature Work Presentation Video