This project investigates and reviews the evolution of the SARS-CoV-2 virus that causes the COVID-19 pandemic from a molecular, genomic, and evolutionary perspective. By incorporating bioinformatics tools, I used sequence data from an open-access database to study the phylogeny of SARS-CoV-2 and examine mutational profiles. With visuals of structural variation of the emerging variants, I reviewed studies and experimental data on the impacts of these mutations on the neutralization of our antibodies. From evolutionary perspectives, the study observed that the SARS-CoV-2 variants have evolved to be more transmissible, though, less virulent. This study has truly captured the essence of an interdisciplinary approach to studying and understanding the complicated issue at a global level, like the COVID-19 pandemic.