SIGNATURE WORK
CONFERENCE & EXHIBITION 2022

Introduction. Cervical cancer causes disproportionate burdens globally and large-scale HPV vaccination is regarded as a promising preventive intervention. To facilitate HPV vaccine policy recommendations for China, identification of potential risk factors contributing to HPV vaccine uptake and cost-effectiveness analysis were performed.

Methods. A multivariate modeling strategy, using the 2016 Uganda Demographic and Health Survey data, was employed to identify and assess potential risk factors associated with HPV vaccination status among Ugandan girls aged 10-14. A cost-benefit analysis was applied to evaluate a hypothetical national HPV vaccination program in China targeting adolescent girls of 10 years of age.
Results. Girls aged 10 (OR 1.24; 95% C.I. 1.02-1.50), 13 (OR 1.29; 95% C.I. 1.07-1.55), and 14 (OR 1.29; 95% C.I. 1.06-1.57), from the Northern region of Uganda (OR 1.74; 95% C.I. 1.18-2.56) and currently attending school (OR 1.78; 95% C.I. 1.41-2.25), had higher odds of receiving HPV vaccines. Being in a family with more than eight members (OR 0.83; 95% C.I. 0.71-0.95) and the second-lowest wealth quintile (OR 0.64; 95% C.I. 0.52-0.79) were associated with significantly lower odds of receiving HPV vaccines. Based on the analysis, HPV vaccination for 10-year-old girls can generate a net present value of $667 million.

Conclusion. The hypothetical HPV vaccination program in China was shown to be beneficial to society from a cost-benefit perspective. In order to better implement such a vaccination program, identified risk factors associated with HPV vaccine uptake in Uganda should be further explored.