SIGNATURE WORK
CONFERENCE & EXHIBITION 2022

Bisphenol A (BPA) is an environmental estrogenic disruption. If exposed BPA on Caenorhabditis elegans, a roundworm, study shows that it will accelerate its aging process by the induction of oxidative stress. There is also some preliminary evidence that BPA can block the trafficking of dopamine transporter in mice. Meanwhile, in C. elegans, dopamine transporter (DAT) helps to translocate released dopamine (DA) from the extracellular space into the presynaptic neuron. Since DA signaling in C. elegans is responsible for basal motor activity, the present study target at the behavioral phenotype, swimming-induced paralysis (SWIP), to conduct the experiment. The phenotype of SWIP relies on endogenous DA release yet as synaptic DAT-1 trafficking and function. Therefore, the aim of this experiment is to conduct the experiment to indicate that BPA can block the DAT signaling and to understand the mechanism of BPA affecting SWIP phenotype. Consequently, the main hypothesis of this aging study can be proved by the experiment results of BPA will decrease the mobility on worms and accelerate C. elegans aging process on lifespan by blocking the DAT.